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Le cause possono essere femminili (30%), maschili (30%), miste (30%) o idiopatiche (senza causa individuata dai metodi di uso abituale) (circa il 10% delle situazioni).
Cause dell'infertilità femminile:
1- Età avanzata della donna, che è associata a una ridotta riserva ovarica
2- Disturbi dell'ovulazione
3- Fattore tubarico (permeabilità tubarica compromessa o inesistente)
4- Endometriosi
5- Fattori uterini: fibromi uterini, polipi endometriali, iperplasia e ipoplasia endometriale
6- Malformazioni del tratto genitale femminile
7- Alterazioni genetiche
8- Malattie autoimmuni, tra altre
